Maternal slimming reprograms metabolic gene expression in mice offspring (NimbleGen expression)

ABSTRACT: Slimming is globally prevalent especially in young women, and it may contribute to the metabolic health of their offspring. Whereas some Lamarckian ideas about environmental inheritance have been dismissed, increasing evidence suggest that certain acquired traits can be transmitted to the next generation. It is therefore of great interest to determine how and to what extent a maternal lifestyle change contributes to their offspring. Here we show that enriched environment (EE) induced maternal slimming improves general health and reprograms metabolic gene expression in mice offspring. EE in mothers induced decreased body weight, adiposity, and improved glucose tolerance and insulin sensitivity. Relative to controls, their offspring exhibited improved general health such as reduced fat accum

ORGANISM(S): Mus musculus

SUBMITTER: yanchang wei 

PROVIDER: E-GEOD-40471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress