Human Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains

ABSTRACT: There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery cohort, and then replicate these aDMRs in sorted CD4+ T-cells and CD14+ monocytes in an independent cohort, suggesting that aDMRs occur in precursor haematopoietic cells. Further replication of the aDMRs in buccal cells, representing a tissue that originates from a different germ-layer compared with blood, demonstrates that the aDMR signature is a multi-tissue phenomenon. Moreover, we demonstrate that aging-associated DNA hypermethylation occurs predominantly at bivalent chromatin domain promoter

ORGANISM(S): Homo sapiens

SUBMITTER: Owen McCann 

PROVIDER: E-GEOD-20242 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress