Hyperthermophilic archaeon Pyrococcus furiosus response to hydrogen peroxide

ABSTRACT: Oxidative Stress Protection and the Repair Response To Hydrogen Peroxide in the Hyperthermophilic Archaeon Pyrococcus furiosus Pyrococcus furiosus is a shallow marine, anaerobic archaeon that grows optimally at 100°C. Addition of H2O2 (0.5 mM) to a growing culture resulted in cessation of growth with a 2 hour lag before normal growth resumed. Whole genome transcriptional profiling revealed that the main response occurs within 30 min of peroxide addition, with the up-regulation of 62 open reading frames (ORFs), 36 of which are part of 10 potential operons. More than half of the up-regulated ORFs are of unknown function while some others encode proteins that are involved potentially in sequestering iron and sulfide, in DNA repair and in generating NADPH. This response is thought to involve

ORGANISM(S): Pyrococcus furiosus DSM 3638

SUBMITTER: Kari Strand 

PROVIDER: E-GEOD-20470 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress