Role of a Candida albicans Whi5/Nrm1 homolog in cell cycle and hyphal-specific gene expression

ABSTRACT: Candida albicans is an opportunistic pathogenic fungus that is able to assume several morphologies, including yeast and hyphal growth forms. The hyphal morphology can be induced by various environmental stimuli and is accompanied by expression of a large set of hyphal-specific genes (HSGs). Cell cycle and morphogenetic programs are interconnected: notably, inhibition of cell cycle progression often causes a switch to filamentous growth. Here we identify and characterize CaNrm1, a C. albicans homolog of the S. cerevisiae Whi5 and Nrm1 transcription inhibitors that, analogous to mammalian Rb, regulate the cell cycle transcription program in the G1 phase and at the G1/S transition. CaNRM1 is able to complement the phenotypes of both whi5 and nrm1 mutants in S. cerevisiae. Deletion of CaNRM1 c

ORGANISM(S): Candida albicans

SUBMITTER: Kathy Barker 

PROVIDER: E-GEOD-20612 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress