Dataset Information
Transcription profiling of human HepG2 cell lines reveals hepatitis C virus core proten induces expression of genes regulating immune invasion and anti-apoptosis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael George
PROVIDER: E-GEOD-2067 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes.
Virology 20060728 1
Hepatitis C virus (HCV) Core protein is implicated in the development of hepatocellular carcinoma (HCC). We utilized a HepG2 human hepatocyte cell line with inducible expression of HCV Core protein (HCV-1b) to investigate the early effects of Core protein on hepatocyte gene expression and to identify molecular processes modulated by the Core protein. A significant change was observed in the expression of 407 genes, which included genes regulating apoptosis, immune response, and cell cycle. Some ...[more]
