Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: cadmium

ABSTRACT: Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene expression following exposure to cadmium. For Cd, the physiological mode of action as indicated by DEBtox model fitting was an effect on energy assimilation from food, suggesting that the transcriptional response to exposure should be dominated by changes in the expression of transcripts associated with energy metabolism and the mitochondria. While evidence for effect on genes associated with energy production were seen, an ontological analysis also indicated an effect of Cd exposure on DNA integrity

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Martijs Jonker 

PROVIDER: E-GEOD-21010 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress