Myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure

ABSTRACT: Impaired myocardial contractile function is a hallmark of heart failure (HF) which may present under resting conditions and/or during physiological stress. Previous studies reported that high fat feeding in HF is associated with improved myocardial contractile function at baseline. Our goal was to determine whether myocardial function is compromised in response to physiological stress and to evaluate the global gene expression profile of rats fed high dietary fat following infarction. Male Wistar rats underwent ligation or sham surgery and were fed normal (10% kcal fat) (SHAM+NC, HF+NC) or high fat (60% kcal saturated fat) (SHAM+SAT, HF+SAT) for 8 weeks. Myocardial contractile function was assessed using a Millar pressure-volume (PV) conductance catheter at baseline, during inferior v

ORGANISM(S): Rattus norvegicus

SUBMITTER: Molly Bray 

PROVIDER: E-GEOD-21021 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress