Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function

ABSTRACT: We compare here the neurodegenerative processes observed in the hippocampus of bitransgenic mice with chronically altered levels of cAMP-response element-binding protein (CREB) function. The combination of genome-wide transcriptional profiling of degenerating hippocampal tissue with microscopy analyses reveals that the sustained inhibition of CREB function in A-CREB mice is associated with dark neuron degeneration, whereas its strong chronic activation in VP16-CREB mice primarily causes excitotoxic cell death and inflammation. Furthermore, the meta-analysis with gene expression profiles available in public databases identifies relevant common markers to other neurodegenerative processes and highlights the importance of the immune response in neurodegeneration. Overall, these analyses defin

ORGANISM(S): Mus musculus

SUBMITTER: Angel Barco 

PROVIDER: E-GEOD-21137 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress