Tobacco smoking transcriptional imprinting contributes to urothelial cancer

ABSTRACT: Smoking is a major risk factor for Urothelial carcinoma (UC). However the complex mechanisms, how smoking promotes carcinogenesis and tumour progression, remain obscure. A microarray based approached was therefore performed to detect the smoking derived gene expression alteration in non-malignant and malignant urothelial tissues from patients with superficial or invasive UC. Smoking enhanced cell migration and response to tissue damages. In non-malignant tissues smoking induced immune response and altered the cytoskeleton. In urothelial carcinoma, smoking altered extracellular and chromosome structures. Smoking affected tissues from patients with invasive carcinomamore strongly, up-regulating particularly growth factors and oncogenes in non-malignant tissue of patients with invasive b

ORGANISM(S): Homo sapiens

SUBMITTER: Li Li 

PROVIDER: E-GEOD-21142 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress