Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus.

ABSTRACT: In this study, we compared the expression profiles of miRNAs in blood samples from Impaired Fasting Glucose (IFG) and T2D male patients. Healthy adult males with no past history of T2D (n=158) and with desirable cholesterol and blood pressure profiles were enrolled in this study. They were then classified according to fasting glucose levels to have T2D, IFG or as healthy controls (CTL), for comparison of miRNA expression profiles. Employing miRNA microarray, we identified ‘signature miRNAs’ in peripheral blood samples that distinguished IFG and T2D. Eight selected miRNAs were further validated using stem-loop real-time RT-PCR. miR-144 expression was found to be dysregulated in Type 2 Diabetes, wherein its expression was significantly higher than in healthy controls. Insulin receptor substr

ORGANISM(S): Homo sapiens

SUBMITTER: Kandiah Jeyaseelan 

PROVIDER: E-GEOD-21321 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress