Physiological and molecular characterization of genetic competence in Streptococcus sanguinis

ABSTRACT: Streptococcus sanguinis is a major component of the oral flora and an important cause of infective endocarditis. The genome sequence of S. sanguinis strain SK36 was recently determined. A number of foreign genes acquired by natural transformation were detected, as well as orthologs of competence genes previously identified in other species. However, significant differences in the S. sanguinis competence system relative to that of other streptococci were noted. We sought to examine S. sanguinis genetic competence, to characterize the global transcriptional response to competence induction, and to compare our results with those obtained from previous analyses of other streptococci. A mutant possessing an in-frame deletion in the comC gene encoding the competence-stimulating peptide was creat

ORGANISM(S): Streptococcus sanguinis

SUBMITTER: Alejandro Rodriguez 

PROVIDER: E-GEOD-21619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress