Transcription profiling of mouse interleukin-10-deficient model for inflammatory bowel disease in C57Bl/6J and C3H/HeJBir strain backgrounds

ABSTRACT: Abstract: Interleukin-10-deficient (Il10-/-) mice serve as a model for inflammatory bowel disease (IBD). The severity of colitis strongly depends on the inbred strain carrying the disrupted Il10 gene: C3H/HeJBir (C3) confers disease susceptibility, whereas C57BL/6J (B6) confers resistance. Genome-wide scans with microsatellite markers on segregrating backcross and F2 populations resulted in the detection of ten colitogenic quantitative trait loci (QTL). The aim of this study was to reduce the large number of candidate genes within the QTL intervals by identifying those genes which are located within the candidate gene intervals and which are differentially expressed in the colon of IBD-susceptible and -resistant strains. Using this combination of QTL mapping and microarray analysis, we ide

ORGANISM(S): Mus musculus

DISEASE(S): inflammatory bowel disease

SUBMITTER: Andre Bleich 

PROVIDER: E-GEOD-2172 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress