Patterns of gene expression and evolution in the human developing cerebral cortex

ABSTRACT: The cerebral cortex underwent a rapid expansion and complexification during recent primate evolution, but the underlying developmental mechanisms remain essentially unknown. In order to uncover genetic networks underlying the development of the human cerebral cortex, we profiled the transcriptome of human fetal cortical domains containing language areas of Broca and Wernicke, as well as associative areas. We thus identified hundreds of genes displaying differential expression between the two areas or between distinct temporal stages. A subset of these genes was further validated by qRTPCR and in situ hybridization, revealing novel patterns of area and layer-specific expression throughout the developing cortex at midgestation, a critical period of cortical patterning. Computational genomi

ORGANISM(S): Homo sapiens

SUBMITTER: Vincent Detours 

PROVIDER: E-GEOD-21858 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress