Transcription profiling of rat aortic smooth muscle cells transfected with dominant negative or upregulated JNK1 and subjected to oxidative stress

ABSTRACT: Oxidative stress-dependent genes are defined as those induced or suppressed by H2O2 treatement in rat vascular smooth muscle cells. JNK-induced genes in rat vascular smooth muscle cells are defined as those induced by adenoviruses encoding constitutively active MKK7 (caMKK7) + wild type JNK1 (wtJNK1) and suppressed by adenovirus encoding dominant negative JNK1 (APF). JNK-suppressed genes in rat vascular smooth muscle cells are defined as those suppressed by adenoviruses encoding constitutively active MKK7 (caMKK7) + wild type JNK1 (wtJNK1) and induced by adenovirus encoding dominant negative JNK1 (APF). Adenovirus encoding nuclear localizing GFP was used as a control.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Hiroki Aoki 

PROVIDER: E-GEOD-2190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress