Growth Hormone Receptor and IGF-I Deficiency is Associated with Resistance to DNA Damage and Very Low Cancer and Diabetes Incidence in Humans

ABSTRACT: Growth Hormone Receptor Deficiency (GHRD) in mice causes life span extension and a major increase in the portion of animals that die without detectable pathologies including cancer and insulin resistance. During a 22-year monitoring of a cohort of 0-88 year old Ecuadorian GHRD subjects with severe IGF-I deficiency developed we observed a single, non-lethal malignancy and no diabetes. To understand the mechanisms responsible for this low disease incidence we incubated Human Mammary Epithelial Cells (HMECs) with serum from either GHRD or control subjects. GHRD serum not only protected mammary cells against hydrogen peroxide-dependent DNA damage but also promoted cell death in severely damaged cells by a mechanism blocked by IGF-I. The gene expression or DNA damage profile in epithelial cells

ORGANISM(S): Homo sapiens

SUBMITTER: Kevin Becker 

PROVIDER: E-GEOD-21980 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress