Hepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function

ABSTRACT: Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. Using a murine model for polymicrobial sepsis we show here that abrogation of APP production by hepatocyte-specific gp130 deletion, the signaling receptor shared by IL-6-family cytokines, dramatically increased mortality despite normal bacterial clearance. Hepatic gp130 signaling through signal transducer and activator of transcription (Stat)3 was required to control systemic inflammation. Notably, hepatic gp130/Stat3 activation was also a prerequisite to facilitate mobilization and tissue accumu

ORGANISM(S): Mus musculus

SUBMITTER: Uta Dierssen 

PROVIDER: E-GEOD-22009 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress