Progesterone-regulated genes in immune cells: Regulation of T cell genes by progesterone

ABSTRACT: We examined the global gene expression pattern of T cells regulated by progesterone to gain further insights into the regulatory mechanisms of progesterone. We found 325-347 cord blood T cell genes up or down-regulated by P4 in the presence or absence of exogenous TGFb1. Peripheral blood T cells were relatively unresponsive with only 30-70 genes regulated by P4. IL-6 receptor (IL-6R) expression was greatly down-regulated by progesterone in cord blood, but not PB, T cells. Overall, these differences in gene expression are consistent with the differential responses of cord blood and peripheral blood T cells to progesterone. To gain insights into the differences of progesterone and control dendritic cells, we performed a microarray study and found ~180 genes regulated by progesterone in dendr

ORGANISM(S): Homo sapiens

SUBMITTER: chang Kim 

PROVIDER: E-GEOD-22025 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress