Transcriptomic effects of combined 17beta-estradiol and progesterone treatment of cultured human uterine smooth muscle cells and of the progesterone inhibitor RU486 (mifepristone)

ABSTRACT: The myometrium is an important reproductive tissue composed primarily of smooth muscle cells. Contractility of the myometrial smooth muscle cells during pregnancy and labour is modulated by hormones. Despite much research, little is known about the molecular mechanism by which estrogen and progesterone regulate myometrial contractility. This study investigates global gene expression profile of cultured human uterine smooth muscle cells (hUtSMCs) following 17β-estradiol (E2) and/or progesterone treatments using cDNA microarray technology. Furthermore the effects of addition of the progesterone inhibitor RU486 were investigated. Many genes were regulated in the presence of P4 or E2 alone but almost six times these numbers were regulated in the presence of the combination. The majority of t

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Cairns 

PROVIDER: E-GEOD-59231 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress