Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

MicroRNAs signatures of Xenopus laevis embryo epidermis at stage 11 (non ciliated) and 26 (ciliated) using high throughput sequencing

ABSTRACT: Epidermis of Xenopus embryos forms a mucociliary epithelium constituted of basal, scattered, secreting and ciliated cells and is histologically similar to human airway mucociliary epithelium. We compared microRNAs signatures of epidermis of Xenopus embryos at stage 11.5 (gastrula, non ciliated epidermis) and at stage 26 (tailbud, ciliated epidermis). 2 technical replicates of a pool of 50 explants for each stage 11.5 (non ciliated) and 26 (ciliated) of Xenopus laevis development

ORGANISM(S): Xenopus laevis

SUBMITTER: Kevin Lebrigand

PROVIDER: E-GEOD-22146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway.

Marcet Brice B Chevalier Benoît B Luxardi Guillaume G Coraux Christelle C Zaragosi Laure-Emmanuelle LE Cibois Marie M Robbe-Sermesant Karine K Jolly Thomas T Cardinaud Bruno B Moreilhon Chimène C Giovannini-Chami Lisa L Nawrocki-Raby Béatrice B Birembaut Philippe P Waldmann Rainer R Kodjabachian Laurent L Barbry Pascal P

Nature cell biology 20110522 6

Multiciliated cells lining the surface of some vertebrate epithelia are essential for various physiological processes, such as airway cleansing. However, the mechanisms governing motile cilia biosynthesis remain poorly elucidated. We identify miR-449 microRNAs as evolutionarily conserved key regulators of vertebrate multiciliogenesis. In human airway epithelium and Xenopus laevis embryonic epidermis, miR-449 microRNAs strongly accumulated in multiciliated cells. In both models, we show that miR- ...[more]

PMID: 21602795

Dataset Information

MicroRNAs signatures of Xenopus laevis embryo epidermis at stage 11 (non ciliated) and 26 (ciliated) using high throughput sequencing

Publications

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway.

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