Erythroid differentiation: Murine erythroleukemia cell induction

ABSTRACT: Transcriptional profiling of murine erythroleukemia cells induced to differentiate Murine erythroleukemia (MEL) cells are derived from mice infected with the Friend erythroleukemia viral complex, which causes a lethal expansion of erythroid cells. The transformed, immortalized cells (MEL cells) isolated from infected mice are committed to erythroid differentiation, but are blocked roughly at the proerythoblast stage. Treatment with small, oxidized organic compounds like dimethyl sulfoxide or hydroxymethyl-bis-acetamide (HMBA) induce the cells to mature further, to roughly the erythroblast stage or beyond in some lines (Friend et al. 1971). During this induction, the amount of hemoglobin, some heme biosynthetic enzymes and other proteins characteristic of mature erythroid cells increases,

ORGANISM(S): Mus musculus

SUBMITTER: Ross Hardison 

PROVIDER: E-GEOD-2217 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress