Comparison of retinal gene expression in wild-type and XOPS-mCFP (rod degeneration) transgenic zebrafish

ABSTRACT: Purpose. XOPS-mCFP transgenic zebrafish experience a continual cycle of rod photoreceptor development and degeneration throughout life, making them a useful model to investigate the molecular determinants of rod photoreceptor regeneration. The purpose of this study was to compare the gene expression profiles of wild type and XOPS-mCFP retinas in order to identify genes that may contribute to the regeneration of the rods. Methods. Wild type and XOPS-mCFP retinal mRNA was subjected to microarray analysis using the Agilent platform. The Ingenuity Pathway Analysis program was used to identify biologically relevant processes that were significantly represented in the dataset. Expression changes were verified by RT-PCR. Selected genes were further examined during retinal development and in adu

ORGANISM(S): Danio rerio

SUBMITTER: Ann Morris 

PROVIDER: E-GEOD-22221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress