Graded Expression Changes Determine Phenotype Severity In Mouse Models of CRX-Associated Retinopathy

ABSTRACT: Background: Mutations in the cone-rod-homeobox protein CRX are typically associated with dominant blinding retinopathies with variable age of onset and severity. Five well-characterized mouse models carrying different Crx mutations show a wide range of disease phenotypes. To determine if the phenotype variability correlates with distinct changes in CRX target gene expression, we perform RNA-seq analyses on three of these models and compare the results with published data. Results: Despite dramatic phenotypic differences between the three models tested, graded expression changes in shared sets of genes are detected. Phenotype severity correlates with the down-regulation of genes encoding key rod and cone phototransduction proteins. Interestingly, in increasingly severe mouse models, the tr

ORGANISM(S): Mus musculus

SUBMITTER: Shiming Chen 

PROVIDER: E-GEOD-65506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress