Insulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms in C. elegans.

ABSTRACT: The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult lifespan in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and HSF-1 are key effectors of the longevity phenotype. We demonstrate that increased intrinsic thermotolerance, due to lower ILS, is not dependent on stress induced HSF-1 transcriptional responses but instead requires active protein translation. Translation profiling experiments reveal genes that are post-transcriptionally regulated in response to altered ILS during heat shock in a DAF-16-dependent manner. Furthermore, several novel proteins are specifically required for ILS effects on thermotoler

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Simon Melov 

PROVIDER: E-GEOD-22383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress