Transcriptome analysis in human kidney to investigate whether fibrosis with inflammation at one year post transplant predicts transplant functional decline

ABSTRACT: We previously observed reduced graft survival for kidney transplants having interstitial fibrosis with subclinical inflammation, but not fibrosis alone, on 1-year protocol biopsy. The current study aimed to determine whether fibrosis with inflammation at 1 year is associated with renal functional decline in a low-risk transplant cohort and to characterize the nature of the inflammation. Subjects were living-donor, tacrolimus/mycophenolate-treated transplant recipients without overt risk factors for reduced graft survival (n=151). Transplants with normal histology (n=86) or fibrosis alone (n=45) on 1-year protocol biopsy had stable renal function between 1 and 5 years, while those having fibrosis with inflammation (n=20) had declining glomerular filtration rate and reduced graft survival. I

ORGANISM(S): Homo sapiens

SUBMITTER: Walter Park 

PROVIDER: E-GEOD-22459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress