Genome-wide expression profiling at maternal-fetal interface in case of recurrent miscarriage (RM)

ABSTRACT: Maternal-fetal interface plays a crucial role to ensure a successful pregnancy. RM (≥3 consecutive pregnancy losses) occurring in 1-3% of fertile couples has a heterogeneous background with contribution from both genetic and environmental factors. As several physiological processes are affected in the pathogenesis of RM, it serves as a good model to study the processes at the maternal-fetal interface. We aimed to map differentially expressed genes and pathways affected in case of RM. Affymetrix® GeneChip® HG-U133 Plus 2.0 Array was applied to placental tissue from 4 RM cases (mean gestational age 63 days) and 6 elective abortions as controls (mean gestational age 62.8 days). Between the two groups 30 transcripts representing 27 genes showed differential expression. 10 genes with the high

ORGANISM(S): Homo sapiens

SUBMITTER: Sulev Koks 

PROVIDER: E-GEOD-22490 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress