Genomic alterations of chromosome 11 induce transcriptomic dysregulation in aggressive and malignant prolactin tumours

ABSTRACT: Pituitary tumors are generally considered as benign. However, many are invasive (45 to 55%) and some are described as aggressive with a high proliferation rate and short post-operative time to recurrence and 0.2% metastasize. The molecular events associated to the progression of the pituitary tumor toward an aggressive and malignant phenotype is still unresolved. To bring new hypothesis on signaling pathways associated to the tumor progression, we applied a wide genome analysis approach combining transcriptome analysis and CGH analysis on the same 13 prolactin tumours classified as non-invasive (n=5), invasive (n=2) and agressive-invasive tumors (n=6). In 5/6 agressive-invasive tumours a loss of a common region in the p arm of the chromosome 11 was detected. This region extending from posi

ORGANISM(S): Homo sapiens

SUBMITTER: Joël LACHUER 

PROVIDER: E-GEOD-22615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress