Transcriptome of the bone metastasis associated stroma

ABSTRACT: The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption, and elicit prevalently an osteoblastic response (osteoinduction). The molecular cues provided by osteoblasts for the survival and growth of bone metastatic prostate cancer cells are largely unknown. We exploited the sufficient divergence between human and mouse RNA sequences together with redefinition of highly species-specific gene arrays by computer-aided and experimental exclusion of cross-hybridizing oligonucleotide probes. This strategy allowed the diss

ORGANISM(S): Mus musculus

SUBMITTER: Wolfgang Raffelsberger 

PROVIDER: E-GEOD-22813 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress