Polycomb function during oogenesis is required for mouse early embryonic development (germinal vesicle oocytes)

ABSTRACT: In mammals, totipotent pre-implantation embryos are formed by fusion of highly differentiated oocytes and spermatozoa. Acquisition of totipotency concurs with remodeling of chromatin states of parental genomes (M-bM-^@M-^\epigenetic reprogrammingM-bM-^@M-^]), changes in maternally contributed transcriptome and proteome, and zygotic genome activation. Genomes of mature germ cells are more proficient in supporting embryonic development than those of somatic cells. It is currently unknown whether transgenerational inheritance of chromatin states present in mature gametes underlies the efficacy of early embryonic development after natural conception. Here, we show that Ring1 and Rnf2, two core components of the Polycomb Repressive Complex 1 (PRC1), serve redundant gene regulatory functions dur

ORGANISM(S): Mus musculus

SUBMITTER: Antoine Peters 

PROVIDER: E-GEOD-23033 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress