Responsiveness of a premetamorphic Xenopus tadpole brain to hydroxylated PCBs

ABSTRACT: Hydroxylated polychlorinated biphenyls are the metabolites produced from polychlorinated biphenyls (PCBs) by drug-metabolizing enzyme cytochrome P450 1A1. These compounds are bound to transthyretin, a major plasma thyroid hormone-binding protein in amphibian tadpoles. The compounds-transthyretin complexes are transferred into the brain across the blood brain barrier in mammals. Thus these compounds are suspected to disrupt neural development in brain. We studied about the effects of hydroxylated PCBs on the thyroid system in brain using metamorphosing tadpoles of African clawed toad, Xenopus laevis. The metamorphosis assay revealed that these compounds had inhibitory effects on the thyroid hormone-induced metamorphosis. This in vivo assay was a powerful tool to detect thyroid-disrupting ac

ORGANISM(S): Xenopus laevis

SUBMITTER: Akinori Ishihara 

PROVIDER: E-GEOD-23154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress