Immunoprotective properties of sertoli cells: potential genes and pathways that confer immune privilege for sertoli cell transplantation and in the testis

ABSTRACT: Immune privileged Sertoli cells (SC) survive when transplanted across immunological barriers and prolong the survival of co-transplanted allogeneic and xenogeneic cells in rodent models. However, the mechanism for this survival and protection remains unresolved. We have recently identified a mouse Sertoli cell line (MSC-1) that lacks some of the immunoprotective abilities associated with primary SC. The objective of this study was to compare the survival and gene expression profiles of primary SC and MSC-1 cells to identify factors or immune-related pathways potentially important for SC immune privilege. Primary SC or MSC-1 cells were transplanted as allografts to the renal subcapsular area of naïve BALB/c mice and cell survival was analyzed by immunohistochemistry. Additionally, transcrip

ORGANISM(S): Mus musculus

SUBMITTER: Timothy Doyle 

PROVIDER: E-GEOD-23200 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress