The immunoregulatory effect of macrophage-specific PPAR gamma deficiency on experimental inflammatory bowel disease

ABSTRACT: Inflammatory bowel disease (IBD) is a condition characterized by severe intestinal inflammation and immune cell activation. The severity of the disease can be mitigated by compounds which activate peroxisome proliferator-activated receptor gamma (PPAR gamma), a receptor present widely in tissues involved in IBD pathogenesis. Our objective was to assess the affect of macrophage-specific deficiency of PPAR gamma on peripheral and colonic immune populations and colonic gene expression in experimental IBD. Macrophage-specific PPAR gamma-deficient mice (PPAR gamma flfl Lysozyme M Cre+) and control (PPAR gamma flfl Lysozyme M Cre-) littermates were treated with 2.5% dextran sodium sulfate (DSS) for 7 days. Disease activity was recorded daily and immune cell populations in the blood, spleen,

ORGANISM(S): Mus musculus

SUBMITTER: Josep Bassaganya-Riera 

PROVIDER: E-GEOD-23421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress