Transcriptional profiling of CD4 T-cells in HIV-1 infected patients

ABSTRACT: HIV-1 elite controllers maintain undetectable levels of viral replication in the absence of antiretroviral therapy, but their underlying immunological and virological characteristics may vary. Here, we used a whole-genome transcriptional profiling approach to characterize gene expression signatures of CD4 T cells from an unselected cohort of elite controllers. In the majority of elite controllers, transcriptional profiles were similar to HAART-treated patients, while being different from HIV-1 negative persons. Yet, a smaller proportion of elite controllers showed an opposite gene expression pattern that was indistinguishable from HIV-1 negative persons, but different from HAART-treated individuals. Elite controllers with this gene expression signature had significantly higher CD4 T cell c

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Woods 

PROVIDER: E-GEOD-23879 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress