Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping

ABSTRACT: Background: We have previously used the rat 4 day Complete Freund's Adjuvant (CFA) model to screen compounds with potential to reduce osteoarthritic pain. The aim of this study was to identify genes altered in this model of osteoarthritic pain and use this information to infer analgesic potential of compounds based on their own gene expression profiles using the Connectivity Map approach. Results: Using microarrays, we identified differentially expressed genes in L4 and L5 dorsal root ganglia (DRG) from rats that had received intraplantar CFA for 4 days compared to matched, untreated control animals. Analysis of these data indicated that the two groups were distinguishable by differences in genes important in immune responses, nerve growth and regeneration. This list of differentially ex

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sarah Smith 

PROVIDER: E-GEOD-24431 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress