Dataset Information


Exon level expression profiling of colorectal cancer tissue samples (validation sample series).

ABSTRACT: Colorectal cancer is a heterogeneous disease molecularly characterized by inherent genomic instabilities, chromosome instability and microsatellite instability. In the present study we propose transcriptome instability as an analogue to genomic instability on the transcriptome level. Exon microarray data from two independent series of altoghether 160 colorectal cancer tissue samples was used for global alternative splicing detection using the FIRMA algorithm (aroma.affymetrix). The sample-wise amounts of these alternative splicing scores exceeding a defined threshold (deviating exon usage amounts) were summarized to provide the basis for description of transcriptome instability. This characteristic was shown to be associated with splicing factor expression levels and patient survival in both independent sample series. We analyzed genome-wide expression at the exon-level for two independent series of colorectal cancer tissue biopsies using the Affymetrix Human Exon 1.0 ST platform. This series of samples represents the validation series.

ORGANISM(S): Homo sapiens

SUBMITTER: Anita Sveen 

PROVIDER: E-GEOD-24550 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2011-05-19 | E-GEOD-24549 | biostudies-arrayexpress
2014-08-13 | E-GEOD-42690 | biostudies-arrayexpress
2011-05-19 | E-GEOD-24551 | biostudies-arrayexpress
2014-05-14 | E-GEOD-57613 | biostudies-arrayexpress
2012-01-05 | E-GEOD-30378 | biostudies-arrayexpress
2011-05-19 | GSE24550 | GEO
2011-05-19 | GSE24549 | GEO
2014-05-12 | E-GEOD-54226 | biostudies-arrayexpress
2010-11-01 | E-MEXP-2469 | biostudies-arrayexpress
2014-01-22 | E-GEOD-53354 | biostudies-arrayexpress