SRSF10 regulates alternative splicing and is required for adipocyte differentiation.

ABSTRACT: During adipocyte differentiation, significant alternative splicing changes occur in association with the adipogenic process. However, little is known about roles played by splicing factors in this process. We observed that mice deficient for the splicing factor SRSF10 exhibit severely impaired development of subcutaneous white adipose tissue as a result of defects in adipogenic differentiation. To identify splicing events responsible for this, RNA-seq analysis was performed using embryonic fibroblast cells. Several SRSF10-affected splicing events that are implicated in adipogenesis have been identified. Skipping of lipin1 exon 7 is controlled by SRSF10-regulated cis-element located in the constitutive exon 8. The activity of this element depends on the binding of SRSF10 and correlates with

ORGANISM(S): Mus musculus

SUBMITTER: Ying Feng 

PROVIDER: E-GEOD-54226 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress