Densely interconnected transcriptional circuits control cell states in human hematopoiesis

ABSTRACT: Tremendous progress has been made in identifying individual transcription factors that regulate hematopoietic differentiation, but many aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression patterns and sequence-based analysis of motifs in gene promoters to decipher the general organization of their regulatory circuitry. We identified modules of highly co-expressed genes, some of which are restricted to a single lineage, but most are expressed at variable levels across multiple lineages. We found densely interconnected cis-regulatory circuits and a large number of transcription factors that are differentially expressed across hema

ORGANISM(S): Homo sapiens

SUBMITTER: Noa Novershtern 

PROVIDER: E-GEOD-24759 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress