Genome-wide expression analysis of the mouse pars tuberalis (PT) under chronic short-day and long-day conditions

ABSTRACT: Living organisms detect seasonal changes in day length (photoperiod), and alter their physiological functions accordingly, to fit seasonal environmental changes. This photoperiodic system is implicated in seasonal affective disorders and the season-associated symptoms observed in bipolar disease and schizophrenia. Thyroid-stimulating hormone beta subunit (Tshb), induced in the pars tuberalis (PT), plays a key role in the pathway that regulates animal photoperiodism. However, the upstream inducers of Tshb expression remain unknown. Here we show that late-night light stimulation acutely triggers the Eya3-Six1 pathway, which directly induces Tshb expression. Using melatonin-proficient CBA/N mice, which preserve the photoperiodic Tshb-expression response, we performed a genome-wide expression

ORGANISM(S): Mus musculus

SUBMITTER: Hiroki Ueda 

PROVIDER: E-GEOD-24775 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress