Dissecting the signalling pathways underlying cellular senescence

ABSTRACT: Cellular senescence is a program of irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in telomeric structure, oncogene activation or oxidative stress. The underlying signalling pathways, potentially of major clinicopathological relevance, are unknown. A major stumbling block to studying senescence has been the absence of suitable model systems because of the asynchrony of this process in heterogeneous cell populations. To simplify this process many investigators study oncogene-induced senescence due to expression of activated oncogenes where senescence occurs prematurely without telomere attrition and can be induced acutely in a variety of cell types. We have taken a different approach by making use of the finding that re

ORGANISM(S): Homo sapiens

SUBMITTER: Parmjit Jat 

PROVIDER: E-GEOD-24810 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress