Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: Tony Ly
LAB HEAD: Tony Ly
PROVIDER: PXD036519 | Pride | 2023-11-27
REPOSITORIES: Pride
Crozier Lisa L Foy Reece R Adib Rozita R Kar Ananya A Holt Jordan A JA Pareri Aanchal U AU Valverde Juan M JM Rivera Rene R Weston William A WA Wilson Rona R Regnault Clement C Whitfield Phil P Badonyi Mihaly M Bennett Laura G LG Vernon Ellen G EG Gamble Amelia A Marsh Joseph A JA Staples Christopher J CJ Saurin Adrian T AT Barr Alexis R AR Ly Tony T
Molecular cell 20231116 22
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER2- breast cancer. We demonstrate that CDK4/6-inhibited cells overgrow during G0/G1, causing p38/p53/p21-dependent cell cycle withdrawal. Cell cycle withdrawal is triggered by biphasic p21 induction. T ...[more]