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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Regulation of early folliculogenesis by Sohlh1 and Sohlh2 in mouse ovary

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE24815: Transcriptional changes in Sohlh1/Sohlh2 double knockout mouse newborn ovaries GSE24816: Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Aleksandar Rajkovic

PROVIDER: E-GEOD-24817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries

Project description:Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. Differential genes expression by both Sohlh1 and Sohlh2 deficiency in mouse newborn ovaries was accessed using microarray. RNA samples from Sohlh1/ Sohlh2 double knockout and wild-type newborn ovaries were arrayed on the Illumina beadchip mouse WG-6 2.0. Total RNA isolated from wildtype and Sohlh1/Sohlh2 double KO mouse newborn ovary were used to run Illumina BeadChip MouseWG-6 2.0 arrays.

2010-10-22 | E-GEOD-24815 | biostudies-arrayexpress

Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries

Project description:Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. We discovered that Sohlh1 and Sohlh2 knockout females lose oocytes after birth and few remains by postnatal day 14. Here, we show that many genes preferentially expressed in the oocytes are misregulated by Sohlh1 and/or Sohlh2 deficiency. Total RNA samples isolated from wildtype, Sohlh1 KO and Sohlh2 KO mouse newborn ovaries were arrayed on the Illumina BeadChip MouseWG-6 2.0 arrays. We have 4 replicates for wildtype and Sohlh1 KO and 3 replicates for Sohlh2 KO.

2010-10-22 | E-GEOD-24816 | biostudies-arrayexpress

Transcriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries

2010-10-22 | GSE24815 | GEO

Mus musculus

Project description:Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries

| PRJNA133645 | ENA

Mus musculus

Project description:Transcriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries

| PRJNA133643 | ENA

Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries

2010-10-22 | GSE24816 | GEO

Expression data from testis of day-7 Sohlh1 knock-out mice

Project description:Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Seven-day-old Sohlh1 or Sohlh2 knockout and wild-type testes were arrayed on the Affy 430 2.0 platform.

2010-04-27 | GSE21525 | GEO

Expression data from testis of day-7 Sohlh1 knock-out mice

2010-05-07 | E-GEOD-21525 | biostudies-arrayexpress

FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation

Project description:Germ-cell transcription factors control gene networks that regulate primordial follicle formation and oocyte differentiation during early, postnatal mouse oogenesis. Taking advantage of gene-edited mice lacking transcription factors expressed in female germ cells, we analyzed global gene expression profiles in perinatal ovaries from wildtype, FiglaNull, Lhx8Null and SohlhNull mice. Figla deficiency dysregulates expression of meiosis-related genes (e.g., Sycp3, Rad51 and Msy2) and a variety of genes (e.g., Nobox, Lhx8, Taf4b, Sohlh1, Sohlh2 and Gdf9) associated with oocyte growth and differentiation. The absence of FIGLA significantly impedes meiotic progression, causes DNA damage and results in oocyte apoptosis. Moreover, we find that FIGLA and other transcriptional regulators (e.g., NOBOX, LHX8, SOHLH1 and SOHLH2) are co-expressed in the same subset of germ cells in perinatal ovaries and Figla ablation dramatically disrupts KIT, NOBOX, LHX8, SOHLH1 and SOHLH2 expression. In addition, not only do FIGLA, SOHLH1 and LHX8 cross-regulate each other, they also cooperate by direct interaction with each during early oocyte development and share downstream gene targets. Thus, our findings substantiate a major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis.

2019-11-06 | GSE139966 | GEO

Genome-wide analysis of gene expression between a mouse genetic model of glioma (Mut6) and an origin cell type (neural stem cells)

Project description:Comparison of gene expression (mRNA) between neurosphere cultures from Mut6 gliomas and wt SVZ neural stem cells (NSCs) Total RNA obtained from neurosphere cultures from Mut6 gliomas was compared to those from wt SVZ

2014-12-08 | E-GEOD-34333 | biostudies-arrayexpress

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