Gene expression of bone marrow fibroblasts from monoclonal gammopathy of undetermined significance and active multiple myeloma.

ABSTRACT: Fibroblasts are a key cellular component of tumour microenvironment, along with other stromal cells playing a critical role in disease initiation and progression (1). In this study, bone marrow fibroblasts deriving from patients with monoclonal gammopathy of undetermined significance (MGUS) or active multiple myeloma (MM) were subjected to global gene expression analysis, in order to identify progression-associated alterations of gene expression. Through immunoselection procedures, primary coltures of bone marrow fibroblasts were established from bone marrow aspirate of 18 patients fullfilling the International Myeloma Working Group diagnostic criteria for MM (n=10) and MGUS (n=8). Differentially expressed genes were investigated through cDNA microarray (21,329 70-mer oligonucleotides;

ORGANISM(S): Homo sapiens

SUBMITTER: angelina boccarelli 

PROVIDER: E-GEOD-24990 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress