Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maciej Geremek
PROVIDER: E-GEOD-25186 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Geremek Maciej M Ziętkiewicz Ewa E Bruinenberg Marcel M Franke Lude L Pogorzelski Andrzej A Wijmenga Cisca C Witt Michał M
PloS one 20140206 2
Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disease characterized by recurrent respiratory tract infections, sinusitis, bronchiectasis and male infertility. The pulmonary phenotype in PCD is caused by the impaired motility of cilia in the respiratory epithelium, due to ultrastructural defects of these organelles. We hypothesized that defects of multi-protein ciliary complexes should be reflected by gene expression changes in the respiratory epithelium. We have previousl ...[more]