Integrated analysis of genome-wide copy number and matched expression data reveals novel genes in esophageal adenocarcinoma

ABSTRACT: The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the west in the last 30 years and 5 year survival remains <14%. We aimed to characterize genome-wide aberrations in esophageal adenocarcinoma to further understand disease pathogenesis and ultimately identify groups with differential survivals with implications for clinical management. Oligo-array-based high-resolution analysis of copy number changes in 89 fresh frozen esophageal adenocarcinoma resection sections with long-term clinical follow-up data was performed. Good quality array comparative genomic hybridization profiles were obtained from 56/89 of the samples (63%). Our analyses confirmed known genomic aberrations in esophageal adenocarcinoma and identified 3 novel genomic regions with copy number chan

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Yi Goh 

PROVIDER: E-GEOD-25201 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress