Microarray gene expression profiling of cardiac genes at the onset of heart failure

ABSTRACT: Atherosclerosis and pressure overload are major risk factors for the development of heart failure in patients. Cardiac hypertrophy often precedes the development of heart failure. However, underlying mechanisms are incompletely understood. To investigate pathomechanisms underlying the transition from cardiac hypertrophy to heart failure we used experimental models of atherosclerosis- and pressure overload-induced cardiac hypertrophy and failure, i.e. apolipoprotein E (apoE)-deficient mice, which develop heart failure at an age of 18 months, and non-transgenic C57BL/6J (B6) mice with heart failure triggered by 6 months of pressure overload induced by abdominal aortic constriction (AAC). The development of heart failure was monitored by echocardiography, invasive hemodynamics and histology.

ORGANISM(S): Mus musculus

SUBMITTER: Ursula Quitterer 

PROVIDER: E-GEOD-25765 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress