Metabolic Transcription Factors Mediate Conserved Functions Largely via Species-Specific Binding Regions

ABSTRACT: The winged helix protein FOXA2 and the nuclear receptor PPARg are highly conserved, regionally-expressed transcription factors that regulate networks of genes controlling complex metabolic functions. Cistrome analysis for FOXA2 in mouse liver and PPARg in mouse adipocytes has previously produced consensus binding sites that are nearly identical to those used by the factors in human cells. Despite this conservation of the canonical binding motif, we report here that the great majority of specific binding regions for FOXA2 in human liver and for PPARg in human adipocytes are not in the orthologous locations to the mouse genome. Nevertheless, gene-centric analysis reveals strong shared transcription factor occupancy near genes in tissue-specific metabolic pathways that are functionally con

ORGANISM(S): Homo sapiens

SUBMITTER: Logan Everett 

PROVIDER: E-GEOD-25836 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress