Distinct Protein Degradation Induced by Different Disuse Models of Skeletal Muscle Atrophy

ABSTRACT: Skeletal muscle atrophy is a consequence of many diseases, environmental insults, inactivity, age and injury. Atrophy is characterized by active degradation and removal of contractile proteins and a reduction in fiber size. Animal models have been extensively used to identify pathways leading to atrophic conditions. Here we have used genome-wide expression profiling analysis and quantitative PCR to identify the molecular changes that occur in two clinically relevant animal mouse models of muscle atrophy, hindlimb casting and Achilles tendon laceration (tenotomy). Gastrocnemius muscle samples were collected 2, 7 and 14 days after insult. The total amount of muscle loss as measured by wet weight and muscle fiber size was equivalent between models, although tenotomy resulted in a more ra

ORGANISM(S): Mus musculus

SUBMITTER: Scott Jelinsky 

PROVIDER: E-GEOD-25908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress