Expression changes after loss of Dot1l in murine MLL-AF9 leukemia cells

ABSTRACT: MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone marrow cells. MLL-AF9 murine leukemia cells carrying two conditional Dot1l alleles were retrovirally transduced with Cre or empty control vector, and gene expression changes were monitored on day 3, 5, and 7 after transduction.

ORGANISM(S): Mus musculus

SUBMITTER: Amit Sinha 

PROVIDER: E-GEOD-25911 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress