Control of heme homeostasis in Corynebacterium glutamicum by the two-component system HrrSA

ABSTRACT: The response regulator HrrA belonging to the HrrSA two-component system (previously named CgtSR11) is known to be repressed by the global iron-dependent regulator DtxR in Corynebacterium glutamicum. Sequence analysis indicated an involvement of the HrrSA system in heme-dependent gene expression. Growth experiments revealed that the non-pathogenic soil bacterium C. glutamicum is able to use hemin or hemoglobin as sole iron source. In DNA microarray analyses a putative operon encoding the hemin-binding protein HtaA and the putative hemin ABC transporter HmuTUV showed a strong upregulation in heme-grown cells. Deletion of the hmu operon clearly affects heme utilization, but does not completely abolish growth on heme or hemoglobin. As a central part of this study, we investigated the regulon o

ORGANISM(S): Corynebacterium glutamicum ATCC 13032

SUBMITTER: Tino Polen 

PROVIDER: E-GEOD-26122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress