Comparison of exon profiles before and after hormone induction

ABSTRACT: Exon array analysis component. Development, differentiation, and response to environmental stimuli are characterized by sequential changes in cellular state initiated by the de novo binding of induced or temporally regulated transcriptional factors to their cognate genomic sites. The mechanism whereby a given regulatory factor selects a limited number of in vivo targets from myriads of potential genomic binding sites is undetermined. Here we show that up to 95% of induced de novo genomic binding by the glucocorticoid receptor, a paradigmatic ligand­activated transcription factor, is targeted to pre­existing foci of accessible chromatin. Factor binding invariably potentiates chromatin accessibility. Cell­selective de novo genomic occupancy patterns appear to be comprehensively pre­determine

ORGANISM(S): Mus musculus

SUBMITTER: Richard Sandstrom 

PROVIDER: E-GEOD-26189 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress