Mapping and analysis of chromatin state dynamics in nine human cell types (gene expression)

ABSTRACT: Chromatin profiling has emerged as a powerful means for annotating genomic elements and detecting regulatory activity. Here we generate and analyze a compendium of epigenomic maps for nine chromatin marks across nine cell types, in order to systematically characterize cis-regulatory elements, their cell type-specificities, and their functional interactions. We first identify recurrent combinations of histone modifications and use them to annotate diverse regulatory elements including promoters, enhancers, transcripts and insulators in each cell type. We next characterize the dynamics of these elements, revealing meaningful patterns of activity for promoter states and exquisite cell type-selectivity for enhancer states. We define multi-cell activity profiles that reflect the patterns of enh

ORGANISM(S): Homo sapiens

SUBMITTER: Jason Ernst 

PROVIDER: E-GEOD-26312 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress